Laboratory animals

Mouse (BALB/cAJcl-nu/nu)

Mice Lacking T-Cell Function

Origin

These mice were introduced by Dr. C. W. Friis (Denmark) to the Central Institute for Experimental Animals; we subsequently started their mass production and supply.

Characteristics

Because of the control from a single recessive gene nu, homozygotes (nu/nu) are anatomically athymic and are hairless in appearance (histologically, hair follicles are present and some animals have downy hair). From an immunologic perspective, they lack T-cell function. They are permanently backcrossed, and the supply of these animals is genetically and microbiologically consistent.

Use

  • Various immunology and cancer studies
  • Screening of anticancer drugs
  • Microbiological studies, etc.

Body Weight Curve

 

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